| Team | Changes |
|---|---|
| El Capitan | |
| Fredonia | |
| Joseph City | |
| Mayer | |
| Mogollon | Moved to 1A East by conference (Moved at 1A/2A/3A conference alignment meeting) |
| Williams |
| Team | Changes |
|---|---|
| Anthem Prep | Moved to 1A North by conference (Moved at 1A/2A/3A conference alignment meeting). Moved to 1A West by appeal (successful appeal 2018-2020) |
| Bagdad | |
| Mohave Accelerated | |
| PDSD | Moved to 1A East by conference (conference alignment meeting) |
| Salome | |
| San Pasqual |
| Team | Changes |
|---|---|
| Baboquivari | |
| Dishchii'bikoh | Moved to 1A East by conference (Moved at 1A/2A/3A conference alignment meeting) |
| Duncan | Moved to 1A South by conference (conference alignment meeting) |
| Fort Thomas | Moved to 1A South by conference (conference alignment meeting) |
| St. David | |
| Valley Union |
| Team | Changes |
|---|---|
| Arete Prep | Moved to 1A East by conference (conference alignment meeting) |
| Hayden | |
| Lincoln Prep | |
| NFL Yet | |
| Ray | |
| Superior Jr./Sr. |